The rising threat of antimicrobial resistance has sparked a global health crisis, with projections indicating 39 million deaths worldwide over the next 25 years. In a significant breakthrough, researchers have discovered a powerful antibiotic that could help combat drug-resistant infections. This move reflects broader industry trends towards exploring unconventional sources for new antimicrobial compounds.
By studying the molecular pathway of the soil bacterium Streptomyces coelicolor, scientists have identified an intermediate compound, premethylenomycin C lactone, with antimicrobial activity 100 times stronger than the final product, methylenomycin A. As Dr. Gregory Challis, a chemical biologist at the University of Warwick, notes, “As humans, we anticipate that evolution perfects the end product, and so you’d expect the final molecule to be the best antibiotic, and the intermediates to be less potent.” However, this finding challenges that assumption, highlighting the potential of intermediate compounds in the development of new antibiotics.
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